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PUBLICATIONS

McNamara T, Liao HY, Weng H, Ito R (2025) Individual and sex differences in frontloading behavior and approach- avoidance conflict preference predict addiction-like ethanol seeking in rats. Scientific Reports 15 (1), 2982

Appings R, Botterill JJ, Zhao M, Riaz S, Kanani A, Violi Fm Steininger CFD, Ito R, Arruda-Carvalho M (2024) Tyrosine hydroxylase–positive nucleus accumbens neurons influence delay discounting in a mouse T-maze task. eNeuro.0487-24.2024

Chow JJ, Pitts KM, Chabot JM, Ito R, Shaham Y (2024) A rat model of operant negative reinforcement in opioid-dependent males and females. Psychopharmacology 241 (9), 1791-1813


Dhawan SS, Pinter C, Lee ACH, Ito R (2023) Rodent perirhinal cortex, but not ventral hippocampus, inhibition induces approach bias under object-based approach-avoidance conflict. eLife 12, e81467

Chu S, Hutcherson C, Ito R, Lee ACH (2023) Elucidating medial temporal and frontal lobe contributions to approach-avoidance conflict decision-making using functional MRI and the hierarchical Drift Diffusion Model.  Cerebral Cortex. 33 (12), 7797-7815 

Yeates DCM, Leavitt D, Sujanathan S, Khan N, Alushaj D, Lee ACH, Ito R (2022) Parallel ventral hippocampus-lateral septum pathways differentially regulate approach-avoidance conflict. Nature Communications 13(1), 1-13

Patterson D, Khan N, Collins EA, Stewart NR, Sassaninejad K, Yeates D, Lee ACH, Ito R (2025) Ventral hippocampus-nucleus accumbens shell circuit drives approach decisions under motivational conflict. PLoS Biology 23 (1), e3002722

Le Duc W, Butler C, Argyropoulos G, Chu S, Hutcherson C, Ruocco AC, Ito R, Lee ACH (2025) Hippocampal damage disrupts the latent decision-making processes underlying approach-avoidance conflict processing in humans PLoS Biology 23 (2), e3003033

Patterson D, Khan N, Collins EA, Stewart NR, Sassaninejad K, Yeates D, Lee ACH, Ito R (2025) Ventral hippocampus-nucleus accumbens shell circuit drives approach decisions under motivational conflict. PLoS Biology 23 (1), e3002722

McNamara T, Liao HY, Weng H, Ito R (2025) Individual and sex differences in frontloading behavior and approach- avoidance conflict preference predict addiction-like ethanol seeking in rats. Scientific Reports 15 (1), 2982

Appings R, Botterill JJ, Zhao M, Riaz S, Kanani A, Violi Fm Steininger CFD, Ito R, Arruda-Carvalho M (2024) Tyrosine hydroxylase–positive nucleus accumbens neurons influence delay discounting in a mouse T-maze task. eNeuro.0487-24.2024

Chow JJ, Pitts KM, Chabot JM, Ito R, Shaham Y (2024) A rat model of operant negative reinforcement in opioid-dependent males and females. Psychopharmacology 241 (9), 1791-1813


Dhawan SS, Pinter C, Lee ACH, Ito R (2023) Rodent perirhinal cortex, but not ventral hippocampus, inhibition induces approach bias under object-based approach-avoidance conflict. eLife 12, e81467

Chu S, Hutcherson C, Ito R, Lee ACH (2023) Elucidating medial temporal and frontal lobe contributions to approach-avoidance conflict decision-making using functional MRI and the hierarchical Drift Diffusion Model.  Cerebral Cortex. 33 (12), 7797-7815 

Yeates DCM, Leavitt D, Sujanathan S, Khan N, Alushaj D, Lee ACH, Ito R (2022) Parallel ventral hippocampus-lateral septum pathways differentially regulate approach-avoidance conflict. Nature Communications 13(1), 1-13

Hamel L, Cavdaroglu B, Yeates D, Nguyen D, Riaz S, Patterson D, Khan N, Kirolos N, Roper K, Ha QA, Ito R (2022) Cortico-striatal control over adaptive goal-directed responding elicited by cues signaling sucrose reward or punishment. J Neurosci 42: 3811-3822

Chu S, Margerison M, Thavabalasingham S, O’Neil EB, Ito R, Lee ACH (2021) Perirhinal cortex is involved in the resolution of learned approach–avoidance conflict associated with discrete objects. Cerebral Cortex

Cavdaroglu B, Riaz S, Yeung EHL, Lee ACH, Ito R (2021) The ventral hippocampus is necessary for cue-elicited, but not outcome driven approach-avoidance conflict decisions: a novel operant choice decision-making task. Neuropsychopharmacology 46:632-642.

Cavdaroglu B, Toy J, Schumacher A, Carvalho G, Patel M, Ito R (2020) Ventral hippocampus inactivation enhances the extinction of active avoidance responses in the presence of safety signals but leaves discrete trial operant active avoidance performance intact. Hippocampus 30:913-925

Yeates DCM, Ussling A, Lee ACH, Ito R (2020) Double dissociation of learned approach–avoidance conflict processing and spatial pattern separation along the dorsoventral axis of the dentate gyrus. Hippocampus 20:596-609

Lee ACH, Thavabalasingam S, Alushaj D, ÇavdaroÄŸlu B, Ito R (2020) The hippocampus contributes to temporal duration memory in the context of event sequences: A cross-species perspective. Neuropsychologia 137: 107300.

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Chu S, Thavabalasingam S, Hamel L, Aashat S, Tay J, Ito R, Lee ACH (2020) Exploring the interaction between approach-avoidance conflict and memory processing Memory 28 (1): 141-156.

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Riaz S, Puveendrakumaran P, Khan D, Yoon S, Hamel L, Ito R (2019) Prelimbic and infralimbic cortical inactivations attenuate contextually driven discriminative responding for reward. Scientific Reports 9(1): 3982.

Schumacher A, Villaruel FR, Ussling A, Riaz S, Lee ACH, Ito R (2018) Ventral hippocampal CA1 and CA3 differentially mediate learned approach-avoidance conflict processing. Current Biology 28:1318-1324.

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Riaz S, Schumacher A, Sivagurunathan S, Ito R (2017) Ventral, but not dorsal hippocampus inactivation impairs reward context memory expression and retrieval. Hippocampus 27:822-836.

Hamel L, Tharangarasa T, Ito R (2017) Caudal nucleus accumbens core is critical in the regulation of cue-elicited approach-avoidance behavior. eNeuro 4.1: ENEURO.0330-16.2017.

Ito R, Lee ACH (2016) The role of the hippocampus in approach-avoidance conflict decision making: Evidence from rodent and human studies. Behav Br Res 313:345-357.

Schumacher A, Sivanandan B, Tolledo EC, Woldegabriel J, Ito R (2016) Different dosing regimens of repeated ketamine administration have opposite effects on novelty processing in rats. Prog Neuropsychopharm Biol Psych 69:1-10

Schumacher A, Vlassov E, Ito R (2016) The ventral hippocampus, but not the dorsal
hippocampus is critical for learned approach-avoidance conflict resolution. Hippocampus. 26:530-542

O’Neil EB, Yang, I, Newsome R, Thavabalasingam, S, Ito R, Lee A (2015) Examining the role of the human hippocampus in approach-avoidance decision-making using a novel conflict resolution paradigm and multivariate functional magnetic resonance imaging. 
J Neurosci 35: 15039-15049

Nguyen D, Schumacher A, Erb S, Ito R (2015) Aberrant approach-avoidance conflict resolution following repeated cocaine exposure. Psychopharmacology 232: 3573-3583

 

Ashwell R, Ito R (2014) Excitotoxic lesions of the infralimbic, but not prelimbic cortex facilitate reversal of appetitive discriminative context conditioning: the role of the infralimbic cortex in context generalisation. Frontiers in Behavioral Neuroscience 8:63

Hayen A, Meese-Tamuri S, Gates A, Ito R (2014) Opposing roles of prelimbic and infralimbic dopamine in conditioned cue and place preference. Psychopharmacology 231:2483-2492

Lansink CS, Jackson J, Lankelma JV, Ito R, Robbins TW, Everitt BJ, Pennartz CMA (2012) Reward cues in space: commonalities and differences in neural coding by hippocampal and ventral striatal ensembles. J Neurosci 32:12444-12459

Van der Meer MAA, Ito R, Lansink CS, Pennartz CMA (2014) Hippocampal projections to the ventral striatum: from spatial memory to motivated behavior. 497-516. Book chapter contribution to ‘Space, Time & Memory in the Hippocampal Formation’, Eds: James Knierem, Dori Derdikman; Springer.

Pennartz CMA, Ito R, Verschure P, Battaglia FP, Robbins TW (2011) The hippocampal-striatal axis in learning, prediction and goal-directed behavior. Trends in Neuroscience 34: 548-559

Ito R, Hayen A (2011) Opposing roles of nucleus accumbens core and shell dopamine in the modulation of limbic information processing. J Neurosci 31:6001-6007

Ito R, Canseliet, M (2010) Amphetamine exposure selectively enhances hippocampus-dependent spatial learning and attenuates amygdala-dependent cue learning.  Neuropsychopharmacology 35:1440-1452

Pennartz CMA, Berke J, Graybiel AM, Ito R, Lansink CS, Van der Meer M, Redish D, Smith KS, Voorn R (2009) Corticostriatal interactions during learning, memory processing and decision-making. J Neurosci 29:12831-12838

Ito R, Robbins TW, Pennartz CMA, Everitt BJ (2008) Functional interaction of the hippocampus and nucleus accumbens shell is necessary for the acquisition of appetitive spatial context conditioning. J Neurosci 28:6950-6959

Ito R, Robbins TW, McNaughton, BL, Everitt BJ (2006) Selective excitotoxic lesions of the hippocampus and basolateral amygdala have dissociable effects on appetitive cue and contextual conditioning in a novel Y-maze procedure. Eur J Neurosci 23:3071-3080

Ito R, Everitt BJ, Robbins TW (2005) The hippocampus and appetitive conditioning: effects of excitotoxic lesions on conditioned locomotor activity and autoshaping. Hippocampus 15:713-721

Ito R, Robbins TW, Everitt BJ (2004) Differential control over cocaine-seeking behavior by nucleus accumbens core and shell. Nat Neurosci 7: 389-397

Ito R, Dalley, JW, Robbins TW, Everitt BJ (2002) Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue. J Neurosci, 22:6247-6253

Ito R, Dalley JW, Howes SR, Robbins TW, Everitt BJ (2000) Dissociation in conditioned dopamine release in the nucleus accumbens core and shell in response to cocaine cues and during cocaine-seeking behavior in rats. J Neurosci 20:7489-7495

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